Levofloxacin is sold under various brand names with Levaquin and Tavanic being the most common, as well as the ophthalmic solutions Oftaquix, Quixin and Iquix. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infections. Levofloxacin is commonly referred to as a fluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials.
Investigation of ofloxacin's racemic nature led to the discovery of a more active l-form, leading to the development of levofloxacin. Chemically, levofloxacin, a chiral fluorinated carboxyquinolone, is the pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin.[1] Often referred to as a "mirror image" of ofloxacin.[2]
Levofloxacin interacts with a number of other drugs, as well as a number of herbal and natural supplements. Such interactions increase the risk of cardiotoxicity and arrhythmias, anticoagulation, the formation of non-absorbable complexes, as well as increasing the risk of toxicity.[3]
Levofloxacin is associated with a number of serious and life threatening adverse reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Such reactions may manifest long after therapy had been completed and in severe cases may result in life long disabilities. Hepatoxicity has also been reported with the use of levofloxacin.[4][5]
Investigation of ofloxacin's racemic nature led to the discovery of a more active l-form, leading to the development of levofloxacin. Chemically, levofloxacin, a chiral fluorinated carboxyquinolone, is the pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin.[1] Often referred to as a "mirror image" of ofloxacin.[2]
Levofloxacin interacts with a number of other drugs, as well as a number of herbal and natural supplements. Such interactions increase the risk of cardiotoxicity and arrhythmias, anticoagulation, the formation of non-absorbable complexes, as well as increasing the risk of toxicity.[3]
Levofloxacin is associated with a number of serious and life threatening adverse reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Such reactions may manifest long after therapy had been completed and in severe cases may result in life long disabilities. Hepatoxicity has also been reported with the use of levofloxacin.[4][5]
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